Selank Reference

Anxiolytic heptapeptide · Approved in Russia (intranasal); research compound elsewhere

ClassAnxiolytic heptapeptide
StatusApproved in Russia (intranasal); research compound elsewhere
Typical vials5 mg, 10 mg
Dose range250 mcg to 750 mcg
FrequencyDaily, as needed
Half-lifeNo human data
Dosing unitmicrograms
RouteIntranasal (primary) or subcutaneous

What Selank is

Selank is Semax's anxiolytic sibling: a synthetic analog of the immune peptide tuftsin, developed by the same Russian institute and approved in Russia as an intranasal anti-anxiety treatment. The pitch is anxiolysis without sedation or dependence, based on Russian trials against benzodiazepine comparators that have not been replicated in the West.

As with Semax, intranasal is the approved and dominant route, and the intranasal calculator covers that math; injection is the minority pattern.

Reconstitution math

Concentration is everything: the same 5 mg vial gives a different draw for every amount of bacteriostatic water you add. The table uses the common 2 mL setup for each vial size, which puts every unit on a U-100 insulin syringe at 25 mcg for the default vial. Dashes mark draws too small to measure or larger than the syringe.

VialBAC waterConcentration250 mcg500 mcg750 mcg
5 mg2 mL2.5 mg/mL10 u20 u30 u
10 mg2 mL5 mg/mL5 u10 u15 u
Selank syringe drawsDRAW GUIDEEach dose as a filled syringe5 mg vial + 2 mL bacteriostatic water = 250 mcg per 0.1 mL (10 units).0481216202428323640units on a U-100 insulin syringe (first 40 units shown)250 mcg10 u (0.1 mL)500 mcg20 u (0.2 mL)750 mcg30 u (0.3 mL)peprecon.com
Draw positions for the common doses at the default setup.

Dosing and protocol

Community protocol: 250 to 750 mcg daily, intranasally or subcutaneously, continuous or as-needed for anxious periods.

Community dosing runs 250 to 750 mcg daily. On a 5 mg vial with 2 mL of water, 250 mcg is a 10-unit draw. Some run it continuously, others keep it as-needed for high-stress stretches; the Russian labeling pattern is short courses of two to three weeks.

Pharmacokinetics

No curve is shown, on purpose.

Selank's published kinetics come from Russian animal work showing blood clearance within minutes; no human subcutaneous pharmacokinetics exist. Like Semax, its claimed effects are central and outlast any plasma level, so a curve would be doubly misleading.

Storage and handling

Lyophilized vials keep best cold, dark, and dry; refrigeration is the community default and freezing lyophilized powder is common for long holds. After reconstitution, refrigerate at 2 to 8 C, do not freeze the solution, and date the vial. Bacteriostatic water's preservative keeps multi-dose use practical for about 28 days by USP convention, though our 120-day stability study found the preservative itself outlasts that window.

Got a certificate of analysis with your vial? Run it through our COA Reader: it reads the report in plain English, checks purity and mass against the label claim, and links the testing lab’s own verification page. Our guide to reading a COA explains what the numbers do and do not tell you.

Sources

  1. Zozulya et al., Efficacy and mechanisms of Selank in anxiety-phobic disorders, Zh Nevrol Psikhiatr 2008
  2. Medvedev et al., Selank in generalized anxiety disorder vs phenazepam adjunct, Zh Nevrol Psikhiatr 2015

Related references: Semax · DSIP · KPV