What Epithalon is
Epithalon (AEDG) is a synthetic tetrapeptide from the Khavinson bioregulator school, studied in Russia for decades as a pineal peptide with claims around telomerase activation and lifespan in animal models. The human evidence consists of small, mostly Russian studies that have not been independently replicated, which puts it firmly in the research-compound category despite its long history.
Community use follows the published course pattern rather than continuous dosing: a 10 to 20 day run of daily injections, repeated once or twice a year.
Reconstitution math
Concentration is everything: the same 10 mg vial gives a different draw for every amount of bacteriostatic water you add. The table uses the common 2 mL setup for each vial size, which puts every unit on a U-100 insulin syringe at 50 mcg for the default vial. Dashes mark draws too small to measure or larger than the syringe.
| Vial | BAC water | Concentration | 5 mg | 10 mg |
|---|---|---|---|---|
| 10 mg | 2 mL | 5 mg/mL | 100 u | - |
| 20 mg | 2 mL | 10 mg/mL | 50 u | 100 u |
| 50 mg | 2 mL | 25 mg/mL | 20 u | 40 u |
Dosing and protocol
Community protocol: 5 to 10 mg daily for a 10 to 20 day course, repeated once or twice a year.
Typical courses run 5 to 10 mg daily, subcutaneously, for 10 to 20 days. On a 10 mg vial with 2 mL of water, a 5 mg dose is a full 1 mL draw, so course users often reconstitute with less water or buy the larger vials.
Pharmacokinetics
No curve is shown, on purpose.
Epithalon has no published human pharmacokinetics. As a four-amino-acid peptide it is expected to clear in minutes, and its claimed effects (telomerase activation, pineal function) are cellular signals that a plasma curve would say nothing about.
Storage and handling
Lyophilized vials keep best cold, dark, and dry; refrigeration is the community default and freezing lyophilized powder is common for long holds. After reconstitution, refrigerate at 2 to 8 C, do not freeze the solution, and date the vial. Bacteriostatic water's preservative keeps multi-dose use practical for about 28 days by USP convention, though our 120-day stability study found the preservative itself outlasts that window.
Got a certificate of analysis with your vial? Run it through our COA Reader: it reads the report in plain English, checks purity and mass against the label claim, and links the testing lab’s own verification page. Our guide to reading a COA explains what the numbers do and do not tell you.
Sources
- Khavinson and Morozov, Peptides of pineal gland and thymus prolong human life, Neuro Endocrinol Lett 2003
- Anisimov et al., Effect of Epitalon on biomarkers of aging, Mech Ageing Dev 2003