Semaglutide Titration Planner

Pre-loaded with the standard semaglutide escalation and its published half-life. Every dose, duration and vial field stays editable.

Compound
Vial setup
mg
mL
Concentration —
Titration schedule
Weeks Dose Frequency Volume / dose Units Total mg
Total weeks —
Total injections —
Total mg needed —
Vials needed —
Drug level over time

Drug level is an estimate of how much drug is in your body across the schedule, in relative units, not an absolute blood concentration. Use it to see how levels build to a steady state, how long that takes, and how a dose change or a gap shifts them. Compare points on the curve to each other, not to a target number.

About this compound

Planning a semaglutide titration

Why the steps are four weeks

Semaglutide has a half-life of about a week, which is why it is dosed weekly and why each escalation step is held for four weeks. Four weeks is roughly four half-lives, the point at which levels from a new dose have substantially settled. Stepping faster means changing the dose before the previous one has finished arriving.

The 0.25 mg start is not a treatment dose

It exists to let the gastrointestinal effects settle. This is the most misread part of the schedule: people conclude the compound is not working during a phase that was never intended to do anything except be tolerated.

What the model does not know

The chart is a one-compartment model from a published half-life, showing shape and timing rather than blood levels. Semaglutide is the most thoroughly trialed compound on this site, but that evidence describes pharmaceutical product; it does not transfer automatically to research-grade vials of unverified content.

Scope & safety

PepRecon is a research and education resource. This page is for informational and laboratory-research purposes only. It is not medical advice, is not a recommendation to use any compound, and is not a protocol to follow. Titration schedules shown here are the ones used in published trials or commonly described in community practice; they are a starting point for modeling, not a prescription. Several compounds discussed here are not FDA-approved and their regulatory status can change. Consult a licensed healthcare provider before making any decision. Calculations run entirely in your browser and are not transmitted or stored unless you generate a share link.

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